To keep it simple, is it possible to have one calculating column that is depended on two columns and takes the sum of them without adding custom javascript for the 3 columns?

Scenario: Column 1 and 2 have editable values if they are changed by the user, it triggers column 3 to calculate the sum of column 1 and 2. Of course, my real scenario involves more than this but this is a start instead of handling everything by hand in javascript.